"Experiments which mimicked a low-calorie diet by tinkering with genes in mice extended their lives and prevented disease, and a drug that has the same effect could give people longer, healthier lives, scientists said on Thursday...
Deleting S6K1 meant the mice's bodies behaved in a similar way to mammals whose calorie intake is restricted, they said.
'These mice were resistant to type 2 diabetes... and they also appeared to have reduced incidence of the mouse-equivalent of osteoporosis -- so they had stronger bones,' Withers said.
Balance, strength and coordination all improved in the knockout mice, and they were more inquisitive, suggesting their brains were healthier...
Most calorie restriction studies have found that a lifetime of deprivation is needed to achieve the longer-life benefits, and many researchers are working on ways to replicate the findings with drugs."
Tuesday, October 06, 2009
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