Blocked receptor may prevent weight gain

"Drug-based weight loss therapies try to stop the brain from sending hunger signals to the body. These therapies tend to be fairly ineffective. Now researchers have discovered that if certain receptors are blocked in mice, they may be resistant to gaining fat...

They found that if they blocked NPY receptors (Y1) in the peripheral tissues of mice fed with high calorie diets, those mice were resistant to gaining body weight and fat."