The novel compound 1a is one of the isoflavone fatty acid esters. In order to investigate the anti-obesity effect of compound 1a and its potential mechanism of influence in adipocyte differentiation, Obese male C57BL/6J mice induced by high-fat diet (HFD) and rat preadipocytes3T3-L1 cellwere used.MethodAfter 4-week HFD induction, the obese model was made successfully...
Conclusion: Compound 1a regulates serum lipid profiles, decreases adipose tissue mass and body weight gain by inducing adipocyte apoptosis in high fat diet induced mice.
Thus, it may be used to treat obese patients with hypercholesterolemia and hypertriglyceridemia.
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