US team may have found key to fight obesity: study

"Shutting down an energy-controlling mechanism in mice left them leaner than normal mice and could be a new way to fight obesity in humans, US researchers said.

And the finding is big news in the United States, where around a third of the adult population is considered obese, meaning they have a body mass index (BMI) greater than 30, according to the American Obesity Association.
BMI is calculated by dividing a person's body weight in kilograms by their height in meters squared.

The researchers found that by switching off potassium channels which are sensitive to adenosine triphosphate (ATP) -- a molecule in cells that stores the energy we need to do just about everything -- made mice burn more energy and left them leaner than normal mice.

The effect was evident even when the mice were fed high-fat 'Western' diets and was long-lasting, too, with the mice remaining slim throughout their lives, scientists from the Mayo Clinic, University of Iowa, University of Connecticut and New York University reported in the journal Cell Metabolism...

One finding was that mice in whom the KATP channel had been switched off burned more glycogen -- the form in which carbohydrates are stored in the body and the primary source of energy for endurance athletes -- and stored body fat than ordinary mice.

That means that achieving greater leanness by deactivating KATP channels comes at the cost of reduced endurance."